在第二个外显子的第11个密码子位置插入了lacZ/neo融合 cassette,取代了这个外显子和整个exon3。 Western blot结果显示,纯合胚胎中没有大型含SH3域的同源物,存在一个大约80-90 kD的缺失SH3域的同源物。(引用文献: J:161922, J:171883, J:172737)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S5/SvEvBrd
Targeted
插入,基因内删除
--
1
1
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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