编码区域的一部分通过同源重组被靶向。整个exon 3(260bp)被替换为包含β-半乳糖苷酶报告基因lacZ和一个floxed诺卡因抗性 cassette的靶向载体。实时PCR分析证实了纯合突变小鼠阴囊白色脂肪组织(eWAT)中mRNA表达的缺失。(来源:J:171883, J:282612)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S5/SvEvBrd
Targeted
基因内删除
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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