通过同源重组,将一个72个核苷酸的成熟microRNA区域替换为一个含pgk-neo标记的假基因 cassette。定量RT-PCR结果显示,双Mir9-2和Mir9-3缺失的纯合小鼠中,RNA表达缺失,并且没有Mir9-1表达的补偿性增加(来源:J:170671)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6NCrlj x CBA/JNCrlj)F1
Targeted
插入,基因内删除
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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