RMCE在KH2细胞中插入了一个包含四环素响应元件(TRE或tetO)和小鼠AP-2γ(cDNA序列)的 cassette,这个元件被插入到了Col1a1基因的3'UTR区域。通过使用多西环素处理,Col1a1基因的Tcfap2c表达在皮肤、肠道和胃中广泛存在,且水平较高,而在心脏、脾脏、胸腺和一些其他器官中则较低。在大脑和睾丸中则未见表达。(来源:J:174049)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(C57BL/6 x 129S4/SvJae)F1
Targeted
插入
--
1
24
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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