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中文
这个靶向载体通过在第17号外显子的CGC替换为TGC，设计成了在第722位氨基酸位置将arginine替换为 cysteine（R722C）。同时，它还包括一个由loxP序列引导的pGK neomycin cassette插入到内含子中，后续通过Cre酶介导的重组会去除neo cassette。来源：(J:171110)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
