在第56个内含子中插入了loxP位点,接着是含氨苄青霉素抗性基因座,其周围由FRT序列标记,随后在第58个内含子中插入了另一个loxP位点。这样,SET域编码的121个氨基酸中的61个被loxP位点包裹。通过后续的Flp介导重组,去除了neo cassette。剩下的序列是57-58号外显子,包括SET域催化核心区域的RYINHS序列,同样被loxP位点围绕。(来源:J:116064)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129X1/SvJ
Targeted
插入
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1
4
4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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