用于同源重组的靶向载体通过BAC重组技术构建。载体包含了tamoxifen诱导的Cre(cre/ERT2)序列、SV40polyA信号以及Frt引导的PGK-neo cassette,它们被定向插入Lrig1的内源性ATG位点。随后,这些转基因动物与表达Flpe的个体杂交,以从生殖细胞中去除neo基因。(来源:J:186084)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S6/SvEvTac
Targeted
插入,基因内删除
--
1
--
36

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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