近端启动子和exon 1被loxP位点前后标记,随后在内含子1的loxP位点下游插入了一个由FRT序列引导的诺姆选择素 cassette。在与Gt(ROSA)26Sor小鼠杂交后表达flp重组酶,随后与Tg(CMV-cre)1Ipc小鼠杂交后表达cre,导致了近端启动子和exon 1的剔除。(来源:J:169834)
Basic Information
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count