近端启动子和exon 1被loxP位点前后标记,随后在内含子1的loxP位点下游插入了一个由FRT序列引导的诺姆选择素 cassette。在与Gt(ROSA)26Sor小鼠杂交后表达flp重组酶,随后与Tg(CMV-cre)1Ipc小鼠杂交后表达cre,导致了近端启动子和exon 1的剔除。(来源:J:169834)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入,基因内删除
--
1
4
10

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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