Tg(UGT1A1*28)1Rhtu

A transgene derived from a human bacterial artificial chromosome (BAC) library, containing the entire human UGT1 (UDP glucuronosyltransferase 1) complex, was modified by targeted mutation of the UGT1 polypeptide A1, UGT1A1, promoter to harbor the UGT1A1*28 mutation associated with hepatic dysfunction found in Gilbert's syndrome. Specifically, this mutation inserts an extra TA in the TATA box sequence of the UGTA1A promoter. Five founders were generated. Founder mice from line 1 carry 6 copies of the transgene on Chromosome 15. (J:102898)