Shroom3^m1Nisw

Following multidose N-ethyl-N-nitrosourea (ENU) treatments to induce mutations in founder C57BL/6J mice, a forward genetic screen was utilized to identify mice exhibiting defects in the closure of embryonic fissures (including the neural tube, body wall, and face). A single nucleotide polymorphism (SNP) was found, resulting in a C to T transition. This caused an arginine to cysteine change in exon 9. (J:169831)