一个包含完整人类LRRK2(富含亮氨酸重复激酶2)基因的188kb细菌人工染色体(BAC)通过靶向修饰,将与早发性帕金森病的常染色体显性遗传型LRRK2 G2019S突变关联起来。(来源:J:169825)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
FVB/NTac
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1
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9

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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