在 intron 3 和 5 处插入了 LoxP 立场。通过 Flp 引导的重组移除了带有 FRT 标记的新 cassette,随后 Cre 引导的重组去除了 exons 4 和 5。转录表达的缺失通过 RT-PCR 验证了(来源:J:169481)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S2/SvPas
Targeted
插入,基因内删除
--
1
--
4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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