Grem1^tm1.1Ecan

This allele was derived from Grem1tm1Ecan by deletion of a frt -flanked selection cassette that, followed by a loxP site, replaced the non-conserved final 66 bp of the 3'-UTR. The present allele contains a loxP site 335 bp upstream of the coding region-encompassing second exon and, within exon 2, the remaining frt site and second loxP site 550 bp downstream of the termination codon. (J:169133)