Nfkbia^tm1.1Smiy

Nucleotide substitutions within exon 1 result in three amino acid substitutions, alanine for methionine at position 45 (M45A), alanine for lysine at position 49 (L49A), and alanine for isoleucine at position 52 (I52A). These mutations disrupt the N-terminal nuclear export sequence. The floxed neo cassette inserted downstream of the modified exon 1 was removed by cre-mediated recombination. (J:168977)