从2号到6号外显子被替换成一个IRES/lacZ/neo插入片段。通过脑组织提取物的 Western blot 分析,证实了没有蛋白质表达(来源:J:168982)
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Exons 2 through 6 were replaced with an IRES/lacZ/neo cassette. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:168982)