Tg(Col2a1*R789C)#Waho

An Arg789Cys mutation (a C-to-T transition in exon 41) was engineered in the murine type II collagen (Col2a1). A second silent mutation was introduced to create a SmaI cleavage site in exon 41 used for monitoring the presence of the transgene. Five founders were created and progeny from two of these founders were analyzed. (J:112540)