在exon 1的内含子末端,插入了一个带有5个密码子连接序列的增强型cre重组酶基因,后面跟着SV40内含子和poly(A)信号序列。Il17a基因的exon 2区域通过点突变去除了一个内部的ATG启动子。位于cre基因下游的耐药性 neo基因座通过FLPe介导的重组被剔除,从而构建出了最终的等位基因。(来源:J:169305)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
Insertion, Nucleotide substitutions
--
1
--
67

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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