在exon 7.1的天冬氨酸262位插入了IRES-β半乳糖苷酶和PGK-诺卡因筛选座。Go1-α基因的同源物被中断,而β半乳糖苷酶则置于Gnao1启动子的调控下。通过免疫学方法确认了脑和胰岛细胞中蛋白产物的缺失。(来源:J:168245)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S7/SvEvBrd-Hprt1b-m2
Targeted
插入
--
1
8
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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