第六外显子的四个核苷酸被修改为(TgCgttggAgaC),编码了一个赖氨酸替换为 cysteine(第163位),同时产生了一个新的BsmBI限制性酶切位点。此外,一个floxed Neo cassette被插入到第六内含子的EagI位点。随后,通过与Alp1tm1(cre)Nagy小鼠杂交,在生殖细胞中完成了选择插件的基因组缺失。(来源:J:168222)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S1/Sv-Oca2+ Tyr+ Kitl+
Targeted
插入
--
1
26
8

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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