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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
基因编辑小鼠
Gt(ROSA)26Sor
tm37(H1/tetO-RNAi:Tafazzin)Arte
Alias:
ROSA26
H1/tetO-shRNA:taz
Gt(ROSA)26Sor
tm37(H1/tetO-RNAi:Taz)Arte
TAZKD
Gt(ROSA)26Sor
tm1(H1/tetO-RNAi:Taz,CAG-tetR)Bsf
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基础信息
表型特征
文献报道
针对Taz的短发夹RNA被定向插入到Rosa26位点。这种shRNA序列由H1/tetO融合驱动的启动子调控。在胚胎干细胞中,确实确认了mRNA的敲除效果。(来源:J:167527)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
4887237
C57BL/6
Targeted
插入
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40
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
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