在exon 4上游插入了一个floxed neo cassette,然后在exon 5下游插入了一个loxP位点。通过Cre介导的重组,neo cassette、exon 4和exon 5被移除。Cre介导的重组去除了neo cassette,留下exon 4和5被标记为floxed。(来源:J:167572)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count