Log In|Sign Up
中文
在Opn4基因的起始密码子后插入了一个人源β-球蛋白内含子和核定位信号，随后是Cre重组酶。接着是一个由FRT标记的pgk-neo载体，它紧跟在Cre编码序列之后。在胚胎干细胞中通过同源重组，这个构建替换了Opn4基因的编码区域。成功建立遗传传递后，这些小鼠与表达Flp基因的动物杂交，通过去除neo cassette，随后通过排除Flp基因来创造纯合突变体。(来源：J:167871)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
