在exon 2的上游插入了一个带有3' loxP位点的FRT引导的neo cassette,然后在exon 5的下游插入了另一个loxP位点。通过Flp介导的重组,neo cassette被移除,使得exons 2到5都被留下了loxP标记。(来源:J:167396)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count