在7号外显子上游插入了一个带有5' loxP位点的FRT引导的neo cassette,接着在7号外显子下游插入了另一个loxP位点。通过Cre介导的重组,删除了7号外显子和neo cassette。蛋白表达缺失通过E18.5时期头部提取物的Western blot分析得到了确认。(来源:J:166870)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6N
Targeted
插入,基因内删除
--
1
2
8

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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