FM1增强子被一个带有neo标记的敲除 cassette 替换,而FM2增强子被一个FRT-介导的puro cassette替换。通过Flp和Cre介导的重组,选择性 cassette 被消除,FM1位置留下一个loxP位点,FM2位置留下一个FRT位点。(来源:J:166617)
Basic Information
(C57BL/6NCrlj x CBA/JNCrlj)F1
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count