Tg(DYRK1A)36Wjs

This transgene consists of a bacterial artificial chromosome clone containing the complete human DYRK1A genomic DNA fragment, including the endogenous promoter (777J19 BAC clone from the RPCI-11 human BAC library). FISH and quantitative PCR analysis shows a single chromosomal integration of the DNA and about a 1.5-fold overexpression of total Dyrk1a (both mouse and human) protein. Two lines 36 and 46 were created, with line 36 entered as the representative line. (J:111293)