一段1.3kb的人类TCL1A编码区域,包括5'和3'的UTR,被置于小鼠Igh-V186.2启动子和Igh-mu增强子序列的调控下。3'UTR和polyA序列取自人类β-珠蛋白基因。Emu增强子驱动B细胞特异性表达。生成了两条转基因小鼠线(线1和4,J:160184)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
FVB/N
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1
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3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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