在exon 1的5'UTR位置插入了一个loxP位点,同时在内含子7中插入了另一个loxP标记,接着是反向排列的FRT引导的诺卡因筛选元件。随后通过暂时的FLP重组酶表达,移除了筛选元件。接着短暂的Cre表达剪除了含loxP标记的exons。这段信息出自文献(J:166040)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129S6/SvEvTac x C57BL/6NCrl)F1
Targeted
插入,基因内删除
--
1
14
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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