A loxP-flanked cassette containg a splice acceptor and beta-geo (E. coli beta-galactosidase (lacZ)/neomycin phosphotransferase fusion gene) has been inserted into the third intron of the gene, whose translation initiation codon is in exon 3. The gene is functionally inactive except in tissues/cells where Cre recombinase is expressed. (J:82809)