在exon 4(最初标记为exon 18)的上游插入了loxP位点,然后在exon 18后面插入了带有FRT和loxP序列的neo cassette。通过Flp酶介导的重组,neo cassette被移除,使得exon 18成为可删除的(来源:J:165879, J:255838)。
Basic Information
129S1/Sv-Oca2+ Tyr+ Kitl+
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count