设计了一个靶向载体,用于在Epsin 3(Epn3)基因起始部位上游插入一个loxP位点。载体包含一个Frt-介导的诺卡因抗性(neo)基因座,后面跟着第二个loxP位点,位于第9外显子下游。通过Cre介导的重组,删除了1到9号外显子和neo基因。胃腺上皮细胞的免疫组化结果显示无蛋白表达,证实了目标。(来源:J:167134)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6J x 129S1/Sv
Targeted
插入,基因内删除
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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