Exon 4被替换为一个,其中的核苷酸替换导致了第111位氨基酸由赖氨酸(K111)替换为阿尔法氨基酸(Alanine),并插入了一个neo cassette。通过Cre介导的重组移除了neo cassette。在E11.5至E12.5期胚胎的提取物中,催化活性未检测到,尽管已经确认了蛋白表达(来源:J:165626)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
Insertion, Nucleotide substitutions
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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