原内源性3' UTR序列被替换为一个由loxP位点、Fos基因的3' UTR、诺如霉素基因、第二个loxP位点以及牛生长激素基因的3' UTR组成的元件。这种改造后的等位基因在低水平表达,而经Cre酶剪切去除第一个3' UTR和诺如霉素元件后,内源基因则过度表达。(来源:J:165111)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S6/SvEvTac
Targeted
插入,基因内删除
--
1
2
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
Show/Hide columns
Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
微信
信息比对
科研助手
使用教程
回到顶部