在第8外显子上游插入了loxP位点,通过同源重组在第8外显子下游插入了loxP位点和FRT介导的neo cassette。随后,Flp酶通过重组去除了neo cassette。(来源:J:165054, J:189065)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count