在exon 2的上游插入了loxP位点,而在exon 4的下游插入了一个由FRT引导的neo cassette,带有3'的loxP位点。通过Flp介导的重组,neo cassette被移除,使得exons 2到4都被留下了loxP标记。(来源:J:165296)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count