在exon 2的第11个密码子后面插入了lacZ基因和一个floxed neo cassette,通过同源重组,这替换掉了exon 2的一部分以及全部的intron 3和exon 3。随后,通过Cre介导的重组移除了neo cassette。RT-PCR结果显示,纯合胚胎中没有表达。(来源:J:164805)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S1/Sv-Oca2+ Tyr+ Kitl+
Targeted
插入,基因内删除
--
1
5
5

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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