dnPAK转基因是通过将p21蛋白(Cdc42/Rac)活化激酶3(Pak3)基因的mouse自抑制域(AID),附带myc标签,并由小鼠钙/钙调素依赖性蛋白激酶IIα(Camk2a)启动子驱动,后面接上Simian病毒40(SV40)的polyadenylation序列设计而成。这个区域在Pak1、Pak2和Pak3这三种基因中都存在。实验产生了Line 21和Line 110(来源:J:90763)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6
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1
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4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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