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中文
整个编码区域和3' UTR的1kb区域通过同源重组被lacZ基因和一个floxed PGK-neo载体替换。通过Cre介导的重组，neo cassette被去除了。RT-PCR、原位杂交和 Western blot分析证实了纯合小鼠中RNA和蛋白表达的缺失。在皮层、海马、纹状体和脑干的神经元中，检测到了β-半乳糖苷酶的表达，这些地方内源性蛋白表达丰富。β-半乳糖苷酶的表达靶向到细胞核。（来源：J:164148）
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
