Tg(Akr1b7-RFP)9Amc

A mouse bacterial artificial chromosome (BAC) containing the entire mouse Akrib7 gene, was modified by inserting the TagRFP-T reporter sequence. Express of the Red Fluorescent Protein (TagRFP-T variant) is under the direction of the mouse Akrib7, aldo-keto reductase family 1, member B7, promoter. Transgene expression is detected at high levels in the adrenal glands and endothelial cells of renal medullary arterioles of transgenic embryos aged E15.5. Renal vasculature associated expression is observed in Smooth Muscle Actin immunohistochemical positive cells that are closely associated with FLK1 and PECAM positive intrarenal arteries. Other possible sites of expression have not been characterized. (J:159099)