Exon 2被用同源重组的方式替换为一个带有floxed neo cassette的元件。随后,通过Cre介导的重组去除了neo cassette。RT-PCR结果显示,IIA转录本已缺失,而E9.5同源纯合胚胎中IIB转录本持续表达。这是一种特异性的基因敲除类型(来源:J:163739)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129X1/SvJ
Targeted
插入,基因内删除
--
1
36
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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