Slco1a5的exons3和4被替换成带有floxed neo cassette的序列,而Slco1b2的exon4则替换为Pgk-thymidine kinase和floxed Pgk-hygro cassette,通过Cre介导的重组移除了Gm5724、Slco1a4、Slco1a1、Gm6614和Slco1a6这些插入序列。转录表达缺失通过在肝脏、肾脏和小肠提取物中进行RT-PCR来验证。(来源:J:163765)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
129P2/OlaHsd
Targeted
插入,基因间区删除,基因内删除
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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