Slco1a5的exons3和4被替换成带有floxed neo cassette的序列,而Slco1b2的exon4则替换为Pgk-thymidine kinase和floxed Pgk-hygro cassette,通过Cre介导的重组移除了Gm5724、Slco1a4、Slco1a1、Gm6614和Slco1a6这些插入序列。转录表达缺失通过在肝脏、肾脏和小肠提取物中进行RT-PCR来验证。(来源:J:163765)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count