构建了一个靶向载体,包含mitogen-激活蛋白激酶8相互作用蛋白1(Mapk8ip1或Jip1)基因的第3外显子。第3外显子的第103位密码子(Thr,对应ACT)被替换为Ala(Gly,对应GCC),即T103A突变。载体下游插入了-loxP引导的诺卡因抗性基因座(neo)。通过Cre介导的重组,删除了neo基因座。(来源:J:163808)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S6/SvEvTac
Targeted
Insertion, Nucleotide substitutions
--
1
1
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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