在内皮5插入了敲除型新霉素抗性基因座,之后在exon 6下游位置插入了第三个loxP位点。实验中,将这些基因敲除的实验鼠与CAG-cre转基因小鼠杂交,以去除内含的敲除型新霉素抗性基因座和exon 6。对来源于肝脏的肥大细胞提取物进行免疫印迹检测,没有检测到蛋白质表达产物。(来源:J:130477)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
B6.Cg-Thy1a
Targeted
插入,基因内删除
--
1
3
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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