设计了一种靶向载体,将一个由loxP序列标记的诺卡因抗性基因置于起始无义密码子上游,接着是loxP序列,位于第一个编码区下游。通过小鼠生殖细胞的Cre介导重组,去除了neo cassette,使得起始两个无义密码子区和第一个编码区周围都留下了loxP序列标记。(来源:J:163376)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S/SvEv
Targeted
插入
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1
8
26

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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