在exon 3的158bp上游插入了loxP位点和frt介导的PGK-neomycin筛选 cassette。紧接着,在同侧exon 3的159bp下游也插入了另一个loxP位点。随后,通过cre酶的剪切,在小鼠中去除了exon 3(来源:J:163029)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6N
Targeted
插入,基因内删除
--
1
2
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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