在exon 3的158bp上游插入了loxP位点和frt介导的PGK-neomycin筛选 cassette。紧接着,在同侧exon 3的159bp下游也插入了另一个loxP位点。随后,通过cre酶的剪切,在小鼠中去除了exon 3(来源:J:163029)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count