通过同源重组,将一个带有polyA序列的cre-ERT2 cassette插入了含小鼠Dbh基因的BAC中,使得cre的表达受Dbh启动子驱动。这个构建整合到了C57BL/6背景中。在与报告线杂交的鼠中,通过他莫昔芬诱导cre活性,显示在交感神经元(包括神经节、肾上腺嗜铬细胞和蓝斑区域)中。(引用:J:163233, J:180731)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6
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6

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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