第18外显子的酪氨酸985位置被替换为苯丙氨酸,并通过同源重组在第18外显子后插入了一个带有loxP标记的neo cassette。随后,通过Cre介导的重组,这个floxed neo cassette被移除,留下一个单独的loxP位点。(来源:J:161732)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129
Targeted
插入,基因内删除
--
1
1
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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