Tg(Myh6-MYL2*N47K)#Dsc

The human ventricular myosin regulatory light chain with an asparagine to lysine substitution at amino acid 47 (N47K, a familial hypertrophic cardiomyopathy-linked mutation) is under the control of about 5.5 kb of the mouse alpha-myosin heavy chain promoter, including the first two exons and part of the third. Six lines (1,2,3,5,6,7) were generated, however the pound symbol (#) is used when the line is not specified or lines are pooled. (J:144685)