插入L1L2_Bact_P cassette在9号染色体(GRCm39基因组构建)产生了649个碱基的缺失,起始于40905571位置,终于40906220。这个缺失导致了功能关键外显子的丢失。该 cassette 包含FRT位点、lacZ序列和一个loxP位点。FRT位点后面跟着由人类β-actin启动子驱动的诺卡因抗性基因、SV40polyA,随后是第二个FRT位点和第二个loxP位点。欲了解针对此类IKMC等变异体的靶向策略详情,请参阅http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml(J:157064)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6N-Atm1Brd
Targeted
插入,基因内删除
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1
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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