在exon 1的上游插入了loxP位点,然后在exon 2的下游插入了一个由FRT引导的neo cassette,它带有3'的loxP位点。通过Flp介导的重组,neo cassette被移除,使得exons 1和2被标记为可剪接。(来源:J:162628)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count